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Thus, genetic and biochemical analyses like the ones described in this paper appear to be essential to decipher the function of specific isoforms, whose levels are moderately altered during Drosophila development.
Studies that identify specific methyl binding proteins, transcriptional activators or repressors and chromatin remodeling will be essential to decipher the exact mechanism of cyclin D2 promoter regulation by SFN.
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Nonetheless, a deeper understanding of combinatorial (or synergistic) effects of various arms of the BDNF signaling cascade may be essential to deciphering new key aspects of gene regulation via BDNF and TrkB in striatal cells.
We show that appropriate large-scale statistical methods are essential to decipher and measure real-time memory traces and neural dynamics.
In order to understand the genetic flexibility it is essential to decipher the organizational logic of transcriptional control.
Accurate quantification of DNA methylation is essential to decipher mechanisms and pathways regulated epigenetically in development and pathogenesis.
It is essential to decipher the molecular and cellular differences amongst the subtypes in order to develop a personalized medicine approach.
Consequently, to understand the role of Oct4/POUV in maintaining pluripotency and supporting embryonic development, it is essential to decipher the function of the network activated by Oct4 and its homologs.
It is essential to decipher a complete genetic makeup of Methylacidiphilum fumariolicum SolV to fully understand the underlying mechanisms used to oxidize methane in the hostile environmental conditions of volcanic and geothermal areas [ 4, 29].
Although it is difficult to reach a consensus about the known cell types that exist in the cortex, the introduction of supervised, or partially supervised algorithms could help advance the state of this key question, which is essential to decipher neocortical circuits.
Histone post-translational modifications (PTMs) direct and regulate chromatin-templated transactions, so understanding the nature and function of pre-deposition maternal histones is essential to deciphering mechanisms of regulation of development, chromatin assembly, and transcription.
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