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Interestingly, the latter molecules were found to be essential regulators of the QS mechanism of several bacteria species [ 35].
At the molecular level, members of the Sirtuins family have been proposed to be essential regulators of lifespan [ 14].
The pro-apoptotic Bcl-2 family proteins Bax and Bak are known to be essential regulators of mitochondrial mediated apoptotic pathways.
Membrane Notch appears to require Numb and Numbl for the negative regulation of β-catenin (Kwon et al., 2011; Andersen et al., 2012), suggesting Numb and Numbl may be essential regulators of Notch and Wnt signaling during CPC development.
In this context, microRNAs (miRNAs) are increasingly considered as promising tools for CHO cell line development as they were shown to be essential regulators of cellular functions that support cell cycle progression and protein expression (for example [ 18– 20]).
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Microtubules are essential regulators of cell polarity, architecture and motility.
Small non-coding RNAs are essential regulators of gene expression at the transcriptional and posttranscriptional levels.
Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function.
Because Cu, Co, and Mn are essential regulators of plant growth and development [24], they are clustered near each other in the nettle leaves.
Protein tyrosine phosphatases (PTPs) are essential regulators of signal transduction pathways, and control, together with protein tyrosine kinases (PTKs), the reversible phosphorylation of tyrosine residues.
Phosphoinositide (PI) 3-kinases are essential regulators of cellular proliferation, survival, metabolism, and motility that are frequently dysregulated in human disease.
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