Sentence examples for be essential for substrate from inspiring English sources

This suggested that the hydroxyl group of Tyr99 might be essential for substrate specificity.

Based on structural and functional analysis of various mutants, two conserved histidine residues were found to be essential for substrate conductance also in the functional eukaryotic ammonium transporters.

Recent biochemical studies have also suggested that the GP-motif may not be essential for substrate binding.

This carboxy-binding motif appears to be essential for substrate binding; arginine reorients in the presence of substrate, co-ordinating the carboxy group of L-tryptophan with both 'open' and 'closed' conformations observed.

These pathways typically rely on substrate binding proteins (SBPs), which are essential for substrate recognition, delivery, and transporter function.

In bacteria, the tRNA-processing endonuclease ribonuclease P is composed of a large (∼400 nucleotide) catalytic RNA and a smaller (∼100 amino acid) protein subunit that is essential for substrate recognition.

Its activity is essential for substrate deubiquitination during proteasomal degradation [46], and may also play a role in the editing of polyubiquitinated substrates as a mean to control degradation, possibly in a proteasomal-independent fashion [47], [48].

Pgp1 has an ATP-binding region that is essential for substrate transport, and the hydrolysis of ATP by Pgp1 ATPase is critical for restoring the transporter to its active conformational state.

We conclude that although the regulatory domains of TRPM6 and TRPM7 show little similarity at the amino acid level, these sequences are essential for substrate phosphorylation by both kinases.

HSP90 is required for LAMP2A oligomerization and stability on the lysosomal membrane, which is essential for substrate translocation.

The pilin VirB2 of A. tumefaciens forms the major pilus component and is essential for substrate transfer.