Sentence examples for be essential for nuclear from inspiring English sources
In addition; CK2 has been found to directly phosphorylate Akt [41], one of several downstream elements of VEGF signaling, and this modification has been shown to be essential for nuclear retention of FOXO1, an important cytoplasmic inhibitor of angiogenesis [42].
Post-translational modification of Bcl-3 via ubiquitination was also shown to be essential for nuclear localization of Bcl-3.
Most importantly, functional BRCA1 was shown to be essential for nuclear focus formation by BACH1, suggesting that BRCA1 plays a role in regulating the cellular localization of BACH1.
In cells, Neat1 was shown to be essential for nuclear paraspeckle assembly and maintenance (Clemson et al., 2009; Sasaki and Hirose, 2009; Sunwoo et al., 2009; Mao et al., 2011a, 2011b; Zhang et al., 2012) and Malat1/ Neat2 binds to the Polycomb 2 (proteinotein which is required for activating growth-control genes (Vance and Ponting, 2014).
On the basis of mapping and deletion mutagenesis experiments, an affinity gradient of FG-binding sites between the nuclear and cytoplasmic faces of the NPC also does not seem to be essential for nuclear transport in yeast (Rout et al. 2000; Strawn et al. 2004).
KERMA factors and DPA cross section data are essential for nuclear heating and material damage estimation in fusion reactor designs.
Using this strategy, we have shown that PKCβ is essential for nuclear envelope breakdown and thus the transition from prophase to metaphase in actively dividing cells.
Besides, a construct encompassing both NLS showed an exclusive nuclear pattern concluding that residues 197 246 are essential for nuclear location.
However, our tests show it is very unlikely that the DNA binding activity of Tus is essential for nuclear targeting.
Towards this aim, we have now performed a systematic investigation under normal and stress conditions of classical nuclear import and key factors that are essential for nuclear trafficking.
Our results indicate that IκBα ubiquitination is essential for nuclear translocation of the NF-κB dimeric complex leading to the regulation of cytokine production.
