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Recently, Hdac8 was shown to be essential for neural crest progenitor cell differentiation and skull bone formation [13].
In contrast, ERK5 was shown to be essential for neural differentiation in Xenopus early embryonic development (37).
Some integrins and extracellular matrix components, along with components downstream of integrin signaling, also appear to be essential for neural tube closure (Brouns et al. 2000; De Arcangelis and Georges-Labouesse 2000; Juriloff and Harris 2000).
Similar to what is observed during dorsal closure in Drosophila, apoptosis does not seem to be essential for neural tube closure, but is required for accelerating the process and ensure zipping.
Further, since PTEN has been shown to be essential for neural development and synaptic plasticity (Kwon et al, 2006; Zhou et al, 2009; Sperow et al, 2011; Takeuchi et al, 2013), upregulation of PTEN may directly contribute to the improved neuronal survival and synaptic function in TFEB-treated Tau mice.
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Fine-tuning of the bone morphogenetic protein (BMP) pathway is essential for neural induction in the developing embryo.
Luan, Z., Liu, Y., Stuhlmiller, T. J., Marquez, J. & García-Castro, M. I. SUMOylation of Pax7 is essential for neural crest and muscle development.
This implies that signaling through WAVE-1 complexes is essential for neural plasticity and cognitive behavior.
PSA-NCAM is essential for neural plasticity [54], [55], [56].
Considering that monopolar cells may be involved in detection of contrast of visual objects, and project axons into the medulla as well as into the lobula, AmFutsch and AmTau might play important roles in stabilizing axon structures, which is essential for neural functions of monopolar cells.
On the other hand, the repression of extrinsic signals is essential for neural fate commitment.
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