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The hedgehog (Hh) signalling pathway is known to be essential for multiple aspects of embryonic development.
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As we discussed in previous sections, apoptosis is essential for multiple physiological processes.
It is a small and highly basic protein, which is essential for multiple stages of the viral replicative cycle, with its structure preserved in all viral strains, including clinical isolates.
Kinetochores are therefore complex dynamic structures that are essential for multiple structural, functional and regulatory tasks during cell cycle progression.
Any disruption of this interaction would prevent re-phosphorylation of PKC which is essential for multiple functions including fatty acid synthesis.
Microtubules are polymers of α- and β-tubulin and are essential for multiple cellular activities, including meiotic and mitotic spindle function.
Microtubules and their dynamic behaviour are essential for multiple steps in mitosis and as such represent good antimitotic targets.
DOI: http://dx.doi.org/10.7554/eLife.02270.015 We report that Pak2, an effector for the small GTPase Rac and Cdc42, is essential for multiple stages of thymocyte development and maturation.
The most represented connector protein is the growth factor receptor-bound protein 2 (GRB2), a widely expressed protein that is essential for multiple cellular functions.
Its establishment and maintenance is essential for multiple cellular processes including cell-cell adhesion, cell-matrix adhesion, protein trafficking, cell shape and the regulation of growth and apoptosis.
Such a xenobiotic-induced increase in [Ca2+] i is of particular concern because this increase, in addition to being essential for multiple physiologic and pathologic processes, is the trigger for vesicular release of neurotransmitters (exocytosis).
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