Sentence examples for be essential for malignant from inspiring English sources

As Hsp90 is known to be essential for malignant transformation and progression 13, 14, inhibiting this molecule would be a good strategy for tumor control.

Importantly, activation of HSF1 is not only a reflection of the transformed phenotype but also appears to be essential for malignant transformation.

Recent studies have identified putative driver genes and aberrant pathways present in endometriotic lesions that may be essential for malignant transformation and the development of OCCC (Wiegand et al, 2010; Yamamoto et al, 2011).

Although these irresponsive genes cannot be considered as markers of T-ALL, they have very important roles in interconnecting numerous DE genes, and their presence could be essential for malignant transformation of precursor T-cells.

Ubiquitin-like with PHD and ring-finger domains 1 is a protein which is overexpressed in various cancers (Mousli et al, 2003; Unoki et al, 2004; Crnogorac-Jurcevic et al, 2005; Jenkins et al, 2005; Lorenzato et al, 2005; Oba-Shinjo et al, 2005) and the overexpression is thought to be essential for malignant cancer progression (Hopfner et al, 2000; Arima et al, 2004; Unoki et al, 2004).

Multiple oncogenic processes are initiated at the cell surface, where KRAS* physically and functionally interacts to direct signalling that is essential for malignant transformation and tumour maintenance.

The recent findings of highly recurrent activating mutations in the promoter for the telomerase reverse transcriptase (TERT) gene in diverse human cancers, together with the widespread mutations in p53 in cancer, provide support for the idea that circumvention of a telomere-p53 checkpoint is essential for malignant progression in human cancer.

This indicates that although multiple oncogenic pathways are regulated by JAK2 activity, not all are essential for malignant cell survival.

The hypothesis of earlier reports was that the disruption of the p16/cdk-cyclin/Rb cascade is essential for malignant cervical transformation/carcinogenesis.

One possible interpretation is that VEGF-D expression is under the control of the c- fos proto-oncogene product, which is essential for malignant progression (Orlandini et al, 1996).

Other studies showed that AURKA affects anchorage-independent growth and invasion, properties that match characteristics that are essential for malignant metastasising cells and therefore may highly influence OS (Zhang et al, 2011; Ratushny et al, 2012; Sillars-Hardebol et al, 2012).