The amino acids that define such distinct features may be essential for directing the paralogues to different targets or functions.
These findings demonstrate that H3K27 demethylation and de-repression of cardiac loci is essential for direct cardiac reprogramming.
Furthermore, it has been suggested that the interaction of pneumococci with neuronal gangliosides is essential for direct bacterial entry into the CNS along olfactory nerves [19].
Cell adhesion via integrin β1 causes activation of hERG1, which is essential for direct FAK phosphorylation.
Therefore, appropriate concentration of GA3 with the auxins is essential for direct and efficient regeneration of binodal explants without callus formation and normal axillary shoot growth in vitro.
The well-conserved BRC repeats in the central part of BRCA2 are essential for direct interaction with RAD51, and this association is critical for HR (11, 139, 140, 151).
Our previous study revealed that CK2 phosphorylation of TEL2 is essential for direct binding to PIH1D1, and its disruption leads to the destabilization of mTOR, SMG1, and, to a lesser extent, ATM, ATR, and DNA-PKcs (Horejsí et al., 2010).
The multisubunit transcription factor TFIID is essential for directing eukaryotic promoter recognition and mediating interactions with activators/cofactors during assembly of the preinitiation complex.
DOI: http://dx.doi.org/10.7554/eLife.02559.002 Sequence-specific transcription factors are essential for directing cellular differentiation and identity.
Bapx1 is the mammalian ortholog of the Drosophila bagpipe, a gene that is essential for directing the development of the fly visceral mesoderm into gut musculature [ 46, 47].
