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WDR5 interaction with the WIN motif of MLL through Arg of MLL has been shown to be essential for complex assembly and resultant H3K4 methylation [ 18, 22].
However, in the case of Sdh1p the assistance of Emi1p (Sdh5p) is required, which is conserved in higher eukaryotes and hence appears to be essential for complex II assembly [52,53].
While in vivo techniques may be essential for complex diseases such as PD, in which discreet populations of neurons are lost, single-gene metabolic neurodegenerative diseases naturally suit the more tractable ex vivo approaches.
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Condition monitoring system is essential for complex mechanical systems [27].
Thus Cdc42 interaction with N-WASP is essential for complex formation and for tubule/vesicle formation.
Like MT-ND4, MT-ND6 is essential for complex I assembly [20].
MT-ND4 has also been implicated in ubiquinone biosynthesis and is essential for complex I assembly [20].
Similarly, the functional glycans were produced abundantly in the Lec1-LG cells deficient in enzyme MgalT1, which is essential for complex N-glycan formation on proteins [23].
All components are essential for complex assembly, substrate selection and protease function [ 19].
Epigenetic modifications are essential for complex regulatory machinery of differential gene expression [ 12].
Under these conditions, complex network activity was blocked (Fig. 8E,G), with ordered firing returning upon washout, indicating that glutamatergic transmission was essential for complex activity (Fig. 8F).
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