Sentence examples for be essential for activation from inspiring English sources

These cell-cycle-regulated loops are shown to be essential for activation of bivalent genes and pluripotency exit.

Unlike Delta and Serrate, however, Dlk1 lacks the DSL (delta/serrate/lag) domain known to be essential for activation of Notch receptors.

Thus, BRM would establish a repressive chromatin conformation where inclusion of H2A.Z would be essential for activation, but in the absence of BRM, the constitutively open chromatin conformation makes H2A.Z superfluous.

Rts1 appeared to be essential for activation, whereas Cdc55 seemed to be inhibitory.

In the study by Mercer et al. (2008), the distal 1-kb of the same 4.4-kb promoter that we have used here proved to be essential for activation of the MMP-1 gene by cigarette smoke extract, a "chemicotoxicologic library" of several thousand compounds, in this respect similar to DEP-bound chemicals.

More importantly, we show for the first time that Src activity is essential for activation of MAPKs by TGF-β and for its stimulation of EMT.

Association of LKB1 with MO25 and STRAD stimulates LKB1 protein kinase activity [2,4] and is essential for activation of AMPK family kinases [7,8].

Smad7 also disrupts the formation of the protein complex TRAF2/TAK1/TAB2/TAB3 (TNF-receptor associated factor 2/TGFβ-activated kinase 1/TAK-binding protein 2/3), which is essential for activation of the inflammation cascade (Hong et al., 2007).

Rad26 is essential for activation of Rad3, which is required for both Cds1 and Chk1 activities [38], [39].

This is essential for activation of DOUBLE TOP and specification of floral identity.

However, the question of how ligand binding induces the conformational changes that are essential for activation remains largely unanswered.