This acetylation of ATM within its regulatory domain is essential for activating ATM's kinase activity.
These polypeptide products, called saposins (Saps, sphingolipidhydrolase activating proteins), are essential for activating a set of lysosomal sphingolipid hydrolases [ 54].
Thus, activation of Raf is essential for activating the Raf/MEK/ERK signaling pathway and many functions attributed to Raf activation are executed by the subsequent activation of MEK and ERK.
Those abilities may be needed to resolve ambivalence toward alcohol addiction and to apply "processes of change", which are essential for activating the desire to change problematic behavior.
The activity tests for high concentration (30%, v/v) of N2O decomposition demonstrated that the BaIrxFe1−xAl11O19 hexaaluminates exhibited much higher activities and stabilities than the Ir/Al2O3-1200, and the pre-reduction with H2 was essential for activating the catalysts.
Additionally, real time RT-PCR analysis suggests that flow induces Wnt5a and Ror2 upregulation, both of which are essential for activating the small GTPase, RhoA, upon flow exposure.
It has been shown that both a sufficient amplitude of calcium current and an appropriate oscillation frequency are essential for activating downstream signaling events [30].
A contiguous pair of highly evolutionarily conserved Oct- and Sox-binding sites is essential for activating expression of genes specific to the pluripotent state in ES cells [23].
On the other hand, in mycobacteria, poly P is essential for activating rel expression at least under a certain set of conditions [17] and subsequent biosynthesis of (p ppGpp.
