Sentence examples for be essential based on from inspiring English sources

The four Arabidopsis poly(A) polymerase genes were found to be essential, based on genetic analysis of T-DNA insertion mutants.

This could explain the result with the STM strains of the argS gene since the arginyl-tRNA synthetase appears to be essential based on our failure to obtain viable argS deletion mutants.

The Corynebacterium glutamicum ortholog (NCgl0187) could not be deleted by Meniche and colleagues [9] and the M. tuberculosis ortholog (Rv3790) is thought to be essential based on a lack of insertions in transposon mutagenesis experiments [14], however, in both cases, direct experimental evidence of essentiality is lacking.

This cut-off was chosen empirically to minimize the number of false positive genes that were considered unlikely to be essential based on their annotation or prior experimental evidence, whilst retaining most known essential genes.

We extracted a list of human proteins that are likely to be essential based on the fact that knockouts of their orthologs in mice are annotated in the Mouse Genome Database as producing pre-, peri- and post-natal lethal phenotypes.

Our previous work with other TS-EL mutants has shown that most conditional alleles are mis-sense mutations, and less frequently splice-site mutations, in genes that are known to be essential based on genome-wide RNAi screens (O'Rourke et al. 2011a).

In Table 4 and 5, there are ~30% of genes in the co-targets set are essential based on the essentiality information retrieved from TB [ 70] and DEG v5.0 database [ 71].

While much digital ink has been spilled on the topic of how to unleash innovation in organizations, here are three ingredients of innovation that I've observed are essential based on my experiences.

Importantly, we revealed that KCBP exhibits non-processive movement by the live-cell, single-molecule (particle) motility assay, and that the second MT-binding domain is essential, based on the genetic complementation tests; our data further support the bundling or crosslinking role of KCBP in the formation of the MT rings at the branching site.

Of the 204 genes with fewer than 10 TA sites, 60 could potentially be scored as essential based on having zero insertions, but do not qualify, given our stringent criteria (Additional file 5: Table S5).

Secondly, if it were a priority, i.e. it was considered as essential based on the disease status or age of household members, particularly spouse and young children, the answer would again be affirmative.