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In addition to the general tasks autophagy performs in neurons, the autophagic machinery appears to be essential also for highly specialized circuits and processes, such as the control of the visual cycle and of satiety.
This cascade was initially thought to respond to stress stimuli only, but was later shown to be essential also for mitogenesis [5], which could be mediated by its role in cell cycle progression [6], [7], and together with ERK2, in oncogenic transformation [8], [9].
Recently they have been argued to be essential also for development [ 50] and stem cell differentiation [ 51].
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The present study shows that GS is essential also for establishment of epidermal permeability barrier.
► OPA1 is essential also for heat shock conditioning.
Finally, p66Shc is essential also for glucose uptake in skeletal muscle cells.
RANKL is the primary mediator of osteoclastogenesis and is essential also for the maintenance and function of mature osteoclasts.
Our studies in megakaryocytic cell lines confirm that iron is essential also for the proliferation of MEGs.
Omp85 is essential also for these, as expected if it evolved prior to all glycobacteria as shown on Figs 3, 7.
Methionine is essential also for cell growth, being a precursor for the aminopropyl moieties of spermidine and spermine, the key polyamines required for transcription and translation, and which stimulate normal and neoplastic cell division.
The notion that business skills are quite essential also for social enterprises is now universally accepted.
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