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The Tolkien suit may prove to be especially troublesome for New Line, if only because it has the earmarks of a public relations nightmare.
In addition to considering the availability of methods to assess specific properties of nanoparticles, the participants noted that methods of addressing traditional challenges of whole animal toxicology tests may be especially troublesome for nanoparticles because of the potential for novel mechanisms of toxicity.
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Fractions are especially troublesome for Americans, the report found.
The drop in business travel is especially troublesome for US Airways, which is struggling to stay in business after emerging from Chapter 11 bankruptcy last year.
With Mrs. Clinton having shown particular strength among working-class white voters in recent big-state primaries, the racial overtones of Mr. Obama's links with Mr. Wright have been especially troublesome for the Obama campaign.
Yahoo's difficulty in gaining traction in social networking is especially troublesome for the company, because it has made a big bet that contributions from users would help differentiate its offerings from those of Google.
Mr. Romney won all these groups in Tuesday's election, except for splitting the very conservative voters with Mr. Santorum, a group that was especially troublesome for Mr. Romney in the Southern states.
This is especially troublesome for drugs produced by joint ventures between foreign and Chinese companies.Bitter medicineOver the past five years, foreign drug companies such as SmithKline Beecham and Schering-Plough have invested nearly $500m in almost 1,500 joint ventures in China.
The problems are especially troublesome for a team that risked everything on the chance that the graying Favre could repeat his remarkable performance of last year, or at least come close.
That does not bode well for the defense, which has ranked 19th, 24th and 21st in the league, something that is especially troublesome for a team whose division opponents finished with offensive rankings of 17 (New England), 24 (Miami) and 30 (Buffalo) this season.
This is especially troublesome for more popular Snapchatters and creators that promote their accounts publicly and let anyone follow them.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com