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Harmonine proved to be equally active against a drug-sensitive Staphylococcus aureus and an multi-resistant S. aureus (MRSA) strain.
In fact, C-seco analogues of SB-RA-2001 SB-RA-2001 SB-RA-2001 be equally active against drug-sensitive and drug-resistant Mtb strains withavegligibeencytotoxicity.
Furthermore, these compounds were found to be equally active against a field isolate of Leishmania donovani resistant to sodium stibogluconate (SbV), suggesting that resistance to SbV does not result in cross-resistance to protease inhibitors.
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These derivatives showed antiplasmodial IC50 values in the range of 0.6 3.0 μM and were equally active against a chloroquine-sensitive and resistant strain of Plasmodium falciparum, while showing little cytotoxicity against a mammalian cell line (CHO).
LabyA1 was equally active against all drug-resistant HIV and HSV strains.
These compounds were equally active against HCMV strains resistant to ganciclovir, foscarnet, cidofovir, and acyclovir as well as mutant strains lacking HCMV protein kinase UL97 and VZV thymidine kinase (VZV-TK).
The most hydrophobic analogue, W LLKK 2W, displayed low selectivity against mycobacteria while peptides with intermediate hydrophobicity were shown to be equally active, yet significantly less toxic.
Although the rate of combined imipenem resistance, meropenem resistance, or doripenem non-susceptibility was high in Turkey and second only to Russia, doripenem was the most active carbapenem against P. aeruginosa, was equally active to meropenem, and was more active than imipenem against Enterobacteriaceae.
Against Enterobacteriaceae, doripenem and meropenem were equally active and at least four-fold more active than imipenem.
It is equally active downstream.
In London, impoverished connoisseurs were equally active.
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CEO of Professional Science Editing for Scientists @ prosciediting.com