Sentence examples for be enriched in stem from inspiring English sources

Intriguingly, the endogenous Pea3 expression profiles that we have observed in mouse mammary gland (Figures 1 and 2) and in the colonic crypt (data not shown) are strikingly similar to those reported for the putative stem cell marker gene Lgr5 [96], giving credence to the notion that Pea3 expression may be enriched in stem cell compartments.

After neoadjuvant chemotherapy in breast cancer, the remaining tumor cells have been found to be enriched in stem cell and EMT markers, 24, 36 indicating that different therapies might be needed to target this population.

Axotrophin is enriched in stem cells, neuronal cells and spermatids [14,16,17].

We also noted that cachectic muscles are enriched in stem cells with myogenic potential, though not in inflammatory cells [ 33].

Our studies indicate that prolonged exposure of the NSCLC cell line H1650 to erlotinib selects for a subpopulation of erlotinib resistant cells which are enriched in stem cell markers and possess stem cell properties in vitro.

Additionally, claudin-low tumours and MBCs are enriched in stem cell-like markers (high CD44/CD24 and CD29/CD24 ratios) and EMT markers (strong SNAI2 and TWIST1 expression in MBCs and strong SNAI3 in claudin-low tumor cells) [ 74].

Our findings that BALL is enriched in stem cell nucleoli and required for the structural integrity of nucleoli in tumourous GSCs provide a plausible link between ribosome biogenesis and BALL-dependent competitiveness of GSCs.

Further studies indicated that human breast cancer cell lines with mesenchymal features are enriched in stem cell-like features [ 21, 22] and recently Rahman et al. [ 19] demonstrated the strongest sensitivity to sTRAIL by this breast cancer subtype.

ALDHbr, side scatter-low (SSClo) populations from murine and human bone marrow (BM) [ 10– 13], umbilical cord blood (UCB) [ 14– 19], cytokine-mobilized peripheral blood [ 20], and circulating blood cells [ 21, 22] are enriched in stem and progenitor cells.

Fillmore et al. showed CD44+CD24neg/lowESA+ in both ER positive and ER negative breast cancer cell lines were enriched in stem cell properties and T-ISC, while the strongly surface CD24 positive CD44+ cells such as we observe in ER positive cancer lines were not (Fillmore & Kuperwasser, 2008).

These results support the hypothesis that sarcospheres are enriched in stem-like cells with enhanced tumorigenic potential and that parental MNNG/HOS cells contain a small fraction of stem cells (able to generate tumors) but most of them are non-stem cells.