From the functional enrichment analysis, we found that the duplicated genes were enriched in olfactory function, whereas the deleted genes were enriched in immune regulation and metabolic processes (Additional file 1 Table S8, Table S9, Table S10, and Table S11).
Moreover, contraction events were also observed in the dolphin lineage, and these were enriched in "Olfactory receptor" gene families (supplementary table S3, Supplementary Material online).
Interestingly, slow-running SNPs have similar conservation scores as quick-running SNPs, and pathway analysis suggests that both these categories of SNPs are enriched in olfactory related genes (supplementary fig. S8, Supplementary Material online).
Using in vitro autoradiography, the olfactory epithelium of smolting masu salmon was found to be enriched in thyroid hormone receptors as compared with that of parr [35].
We chose Elavl4 (Hud) as a marker that should be enriched in the FNP as this gene is associated with neurogenesis and is expressed in the developing olfactory epithelium of the nasal pit [27].
Moreover, miR-200b is enriched in zebrafish olfactory bulb; miR-124 and miR-9 expression are detected throughout adult brain [ 16].
Curiously, those SNPs are enriched in genes performing olfactory transduction function (supplementary fig. S8, Supplementary Material online), which are known to be under positive selection in human evolution (Young and Trask 2002).
In addition, we show that Fucα(1−2 Gal glycoproteins are enriched in the developing mouse olfactory bulb (OB) and exhibit a distinct spatiotemporal expression that is consistent with the presence of a "glycocode" to help direct olfactory sensory neuron (OSN) axonal pathfinding.
It is enriched in the basal ganglia, hippocampus, olfactory bulb, and cortical areas, and plays a role in motor and cognitive functions.
(B ) ArhGAP44 is enriched in the cerebral cortex and olfactory bulb.
