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miR-107 was also shown to be enriched in brain tissues (3.25-fold, P < 0.0001).
We designed primers to amplify 10 up-regulated and 3 down-regulated genes, choosing genes that are predicted to be enriched in brain, fat body or both tissues based upon FlyAtlas expression data [ 53].
Furthermore, recently identified methyl-cytosine derivatives such as hydroxyl-methyl-cytosine would not be distinguished from 5-methyl-cytosine, so our analysis was not sensitive to differential proportions of such variants, which have been reported to be enriched in brain (39).
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In addition we have identified that neurotransmitter signaling, regulation of IL-2, and other pathways are enriched in brain endothelial cells.
Here we show that expression of PD-associated genes in blood is enriched in brain tissue.
Surprisingly, 50%% of them were enriched in brain [ 24] (Table 2a).
Both PE and PS are enriched in brain lipids, and in previous studies, this membrane composition was shown to be stable.
miR-124 is enriched in brain tissue and its over expression in neural stem cells induces differentiation [ 32].
SNX16 is enriched in brain and muscles in mouse [ 31], so we tested whether SNX16 is distributed to the cell cortex in these tissues.
miR-103, miR-195 and miR-497 were expressed at similar levels across various tissues, whereas miR-107 is enriched in brain samples.
We identified pathways that are enriched in brain tissue models i.e., pathways with more reactions present in normal brain tissues than in normal non-brain tissues (Table 3).
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