The known role of Dig1 and Dig2 in regulating mating-specific and pheromone-responsive genes is confirmed by the enrichment of these functional categories in Cluster 3. Also, binding sites of TFs Tec1 and Ste12, which together with Dig1 form a regulatory complex involved in mating and filamentation [ 28], are enriched for Cluster 5 and Clusters 3 and 5, respectively.
Metagenomes from 'specific gene cluster hotspots' are predicted to be enriched for a gene cluster that encodes a congener of the target natural product, while metagenomes from 'gene cluster family hotspots' are predicted to encode multiple congeners related to the target natural product.
The robustness of the approach is confirmed by the fact that (i) several motifs corresponding to nuclear receptors are found to be enriched for the transient cluster analyzed here, and (ii) applying this method to other clusters identifies further motifs corresponding to nuclear receptors, corresponding well to the fact that these clusters must have strict temporal control.
Interestingly, these DEGs are surface interferon receptors and were also found to be enriched for the same functional clusters in all regions of the brain assessed regardless of developmental stage.
We hypothesized that these miRNA clusters would be enriched for miRNAs that are involved in direct regulation of the distinct phenotypic differences.
Hence, we might expect that a good clustering will be enriched for gene functions, as defined by the GO ontology.
As a result, orbits 8 and 9 will be enriched for edges belonging to highly connected clusters.
Therefore, we expected a small number of the clusters to be enriched for genes related to the EMT process (see 'Mining for Genes Associated with EMT').
Furthermore, whereas cluster I was enriched for CUTs, clusters II and III contained more SUTs (Table S2), revealing differences not readily apparent from the class-wide analysis in Figure 1.
Upon visual inspection of phased sequence alignments, we noticed that Yorkshire and Landrace genomes are enriched for large clusters of SNPs in strong linkage disequilibrium (LD).
