Sentence examples for be enriched for binding from inspiring English sources

Combinatorial regulation is a fundamental and an increasingly central aspect of transcriptional control in higher eukaryotic cells, and we therefore hypothesized that (i) the ARORs might be enriched for binding sites for both AR as well as AR-coregulators, and (ii) the presence of such sites modulated responsiveness to DHT in a combinatorial manner.

We compared transcription factor (TF) binding to memory effect and transcriptionally responsive genes using the CERES web tool (Morris et al. 2009) and found neither class to be enriched for binding sites for any specific TF (including Hsf1, which could conceivably be responsible for activating memory effect genes after the temperature shift to 37°).

Accordingly, EFL-1−bound genes are enriched for binding of MES-4 and H3K36me3 in wild-type animals, an enrichment that is lost in MES-4−depleted animals.

Upon ESC differentiation, most of these binding sites disappear and instead new CTCF independent RAD21 binding sites emerge, which are enriched for binding sites of transcription factors implicated in early differentiation.

We observe that mRNAs with a structure prediction in their UTRs are enriched for binding, transport and localization gene ontology categories.

In the signed network the black, brown, and red modules are enriched for binding by transcription factors in the Oct4 and cMyc groups and are under-enriched for Suz12 binding.

Another plausible explanation for our results is that the new predictions are enriched for binding sites of a small number of TFs that, for an unknown reason, show exceptionally good correlations between PWM score and expression change.

In addition, we also used expression profiling of each of the diseases, to see if genes differentially expressed in the disease were enriched for binding sites of the predicted TF (See Supplementary Materials for details).

For instance, B-cell eCGIs are enriched for regions binding key TFs involved in B-lymphopoiesis and lymphoma pathogenesis (such as BCL11A, EBF1, IKZF1 and SPI1), whereas ESC-specific eCGIs are enriched for binding of NANOG, a key TF regulating pluripotency (43, 44).

Many of these footprints coincide with the boundaries of antisense transcripts, and the most significant footprints are enriched for binding sites of the chromatin-associated factors Abf1 and Rap1.

Using ChIP-Seq, Vahedi et al. [ 55] revealed that Th1 enhancer elements (defined by Th1-specific p300 binding in the absence of H3K4me3) were enriched for binding of STAT1 and STAT4 in Th1 cells and instead for STAT6 in Th2 cells.