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We speculate that this combination might be enriched for a particular subtype of heterochromatin.
While many probes of homologous genes can be enriched for a GO signal, a limitation of this previous study is that this geneset-based approach is not designed to impute differential expression of individual mouse stromal genes.
Consistent with this view, FRDA patient alleles have been shown to be enriched for a variety of histone modifications characteristic of silenced genes including hypoacetylated H3 and H4 and dimethylation and trimethylation of histone H3 lysine 9 (H3K9) [ 48, 50].
If the advantage to the cell centered on the functions associated with the genes in the duplicated regions, then these regions relative to other regions may be enriched for a function.
Metagenomes from 'specific gene cluster hotspots' are predicted to be enriched for a gene cluster that encodes a congener of the target natural product, while metagenomes from 'gene cluster family hotspots' are predicted to encode multiple congeners related to the target natural product.
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Using the input data set (human homologs of zebrafish genes differentially expressed in the mib mutants), IPA identified a set of genes that are enriched for a particular function or pathway and the enrichment is represented as ratio.
After conversion to human homolog genes, these homologs were submitted to IPA, sets of genes that were enriched for a particular function or pathway were identified, and enrichment ratios were calculated.
Lung metastases were enriched for a number of chromatin-modifying genes and stem cell-associated genes.
This feature can be useful for determining how prior knowledge categorization compares to data driven clustering, and whether a cluster is enriched for a specific category.
The balanced gene groups are enriched for a multitude of regulatory functions and indicate a stronger sensitivity to gene dosage effects for the main regulatory networks.
Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
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CEO of Professional Science Editing for Scientists @ prosciediting.com