The activity of eIF4A is enhanced by binding of eIF4G-HEAT1.
The GCK GKRP interaction is enhanced by binding of the glycolytic intermediate fructose-6-phosphate (F6P) to GKRP, and is reduced by binding of fructose-1-phosphate (F1P).
In these cases, the reactions of these molecules are enhanced by binding into active sites to lower the transition state and then reacting to quench activity.
While the stability of curcumin is enhanced by binding to Aβ42, there is still significant degradation over the time course of these experiments and consequently the degradation products may contribute to capping of the low MW oligomers.
Other upregulated genes are Bcl2l1 (also known as Bcl2-like1 and Bcl-xl), an anti-apoptotic protein that is enhanced by binding to the Gadd45 family [ 46, 47], and Dusp1, a p53 target gene involved in cell cycle regulation [ 48].
To examine whether CCL2's capacity to induce migration is enhanced by binding to versican's CS chains, we performed migration assays in a TransWell® double-chamber system using CD14+ monocytes derived from healthy controls and SSc patients.
Consistent with a function in transcription, we show that sumoylation in vitro is enhanced by binding to intact, but not to damaged DNA, in a manner clearly distinct from the mechanism by which DNA damage stimulates PARP-1's catalytic activity.
Additionally, in preclinical studies, PTX transport across the endothelium was enhanced by albumin receptor-mediated transcytosis, and PTX delivery to tumors might be enhanced by the binding of albumin-bound PTX to interstitial albumin-binding proteins such as secreted protein acidic and rich in cysteine.
This supports the idea that chemoreceptor interactions can be enhanced by membrane binding (Shrout et al., 2003), but in the absence of a membrane, this can be achieved by molecular crowding and sandwiching (Fowler et al., 2010).
