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Intestinal K cells are glucose-responsive endocrine cells that might be engineered to secrete insulin.
Tumor cells can also be engineered to secrete cytokines and chemokines.
Yersiniae can be engineered to secrete or translocate heterologous antigens into the cytosol of antigen-presenting cells by their type 3 secretion system (T3SS).
Several studies indicate that liver cells can be engineered to secrete biologically active insulin [ 12- 14].
Filamentous fungi can be engineered to secrete high levels of protein for a wide range of industrial applications (Arora 2003; Tian et al. 2009).
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The first system utilizes attenuated strains of Gram-negative bacteria which are engineered to secrete heterologous antigens via the α-hemolysin secretion system (type I) of Escherichia coli.
The vaccine was engineered to secrete IL-12 and IL-18 by means of the EBV/lipoplex.
HuMSC were engineered to secrete human Erythropoietin, Interleukin (IL- 3, or IL- 3 using MoruLV-based retroviral vectors.
We generated an EL-4 lymphoma cell line (herein named EL-4-IL-33) that was engineered to secrete an active form of IL-33.
METHODS: Nonimmunogenic, murine pancreatic cancer cells (Panc02) were engineered to secrete IL-2, IFN-gamma, IL-2 and IFN-gamma, or neomycin phosphotransferase.
In this study, we demonstrate high levels of glucokinase mRNA in the anterior pituitary cell line AtT20ins, which has been engineered to secrete correctly processed insulin, as well as in primary anterior pituitary tissue.
More suggestions(16)
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