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These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology.
They can be engineered to respond to almost any ligand of choice and are, therefore, of great interest for applications in synthetic biology.
The sensitivity of vesicles to toxins was tuned by altering the lipid and fatty acid composition of the membranes such that vesicles could be engineered to respond to toxins/enzymes from S. aureus only; P. aeruginosa only; and both S. aureus and P. aeruginosa.
Cells involved in the manufacturing of biologics, such as the workhorse Chinese hamster ovary (CHO) cell line, could be engineered to respond to inducers that stage a multistep production process.
It has been demonstrated that cells, harboring the type II interleukin-4 receptor but lacking the downstream signaling pathway, can be engineered to respond to interleukin-4 by the expression of human STAT6 [ 13, 14].
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Designer ribozymes are engineered to respond to different effectors by in vitro selection, rational and computational design methods.
Governments and political processes in Western countries are unable to satisfy this major social demand since the political system, the dominant ideology and the economic tools have been engineered to respond to different basic needs.
For example, anticancer therapies could be engineered to detect and respond to complex cellular conditions in individual cells with high specificity.
Alternatively, tumor-specific donor T cells can be engineered to overexpress IL-7Rα to allow them respond to exogenous IL-7 after transfusion.
Perhaps their most important characteristic, based on recent developments in genetic engineering technology, is that prokaryotic cells can be molecularly engineered to respond in a dose-dependent manner, to yield readily quantifiable optical (colorimetric, fluorescent, or luminescent) or electrochemical signals to predetermined targets such as chemicals, biomolecules, or biological effects [ 3].
Several enzymes, catalyzing easily measurable reactions, have been engineered to allosterically respond to specific ligands, being themselves the main constituent of new-generation biosensors.
More suggestions(19)
be engineered to accommodate
be redesigned to respond
be engineered to detect
be added to respond
be attacked to respond
be forced to respond
be engineered to express
be engineered to permit
be engineered to resemble
be engineered to shut
be engineered to form
be engineered to meet
be engineered to provide
be seen to respond
be engineered to carry
be determined to respond
be engineered to reach
be engineered to clean
be engineered to treat
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