Sentence examples for be engineered to bind from inspiring English sources
Our results also demonstrate that peptides can be engineered to bind to specific faces of COM crystals.
Zinc finger arrays in ZFNs can be engineered to bind target DNA sequences of interest [10] [17], thereby enabling the introduction of double-strand DNA breaks (DSBs) into specific genomic sequences.
Importantly, we demonstrated that multiple loops of a knottin peptide, comprising 21 non-native amino acid residues, can be engineered to bind with high affinity to integrin receptors, and the resultant peptide can be used as a probe for non-invasive molecular imaging applications.
Interlocked structures can be engineered to bind specific guests within the topologically constrained three-dimensional cavities created during their template-driven syntheses.
The DNA-binding domain may be a synthetic zinc finger (ZF) or a TAL protein (TALE), which can be engineered to bind to a DNA sequence of choice.
TALE proteins can be engineered to bind next to the promoter of a gene of interest and fused to transcriptional activators such as VP16 to generate custom transcription factors (Miller et al. 2011).
It has been engineered to bind highly to penicillin binding protein 2a (PBP2a).
When introduced into an Fc fragment that had been engineered to bind to Her2/neu via a novel antigen binding site located at the C-terminus of the CH3 domain, the novel inter- and intra-domain bonds also brought about a significant increase in thermostability.
PUM-HD domains have also been engineered to bind to cytosine (which is not observed in any of the natural PUF binding specificities) and to bind targets longer than 8 bases by increasing the number of repeats [ 32, 33].
For that reason, and the lack of alternative therapies, America's Food and Drug Administration has recently agreed to expedite the review process for these two potential treatments.Unlike most antibodies, MEDI3902 is bi-specific meaning it has bi-specific meaningbitd to two different targets.
