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When side effects do manifest in preclinical species or in clinical trial participants, human genetics of the target can be used to build hypotheses of whether the side effects are target-mediated phenotypes intrinsic to the therapeutic mechanism, or off-target effects that could be engineered out of the drug.
By employing the methods of Health Effects Engineering, one can determine not only which fuel attributes are likely to contribute to lung injury, but also how tendencies of the ash to cause lung injury can be engineered out of the combustion process.
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Mistakes were engineered out of a recording with edits from numerous retakes.
Like sneakers, an office chair is an everyday object that has often been engineered out of all proportion to its size or function.
Planes are already so automated, consensus has it, that it's only a matter of time before pilots are engineered out of the picture completely.
In the introductions of several new models here, including "S" performance versions of all its larger sedans, company executives highlighted how many pounds had been engineered out of each.
"It's surprising that the human side has been engineered out of the equation". Reiley, a roboticist who studied at Johns Hopkins and previously worked on medical robots, says the company is unique in applying machine learning to both driving and human interaction.
With people more likely to be locking eyes with their smartphone screens these days when they're hanging around in public, the London-based designers behind this feathery wearable are worried that the chances for exchanging flirtatious glances with passing strangers is being engineered out of daily life.
The offer was not accepted but relations between the two parties remained good enough for the deal of the season to be engineered almost out of the blue.
The targeting vector can be engineered to knock out the whole gene or part of a gene, or small changes can be introduced into the gene sequence.
The architect, Rafael Viñoly, maintains that such measures were part of the original design, but they were "value engineered" out of the scheme.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com