Two COX isoforms, COX-1 and COX-2, which are encoded by distinct genes, have been described in mammalian cells.
AGPP is comprised of two large subunits and two small subunits, each of which is encoded by distinct genes.
AGP is composed of two large subunits and two small subunits, each of which is encoded by distinct genes (AGPP-L and AGPP-S).
The current study reports the use of baculovirus system to express functionally active human recombinant 3-methylcrotonyl-CoA carboxylase (MCCC), a heteromultimeric complex that is composed of α and β subunits which are encoded by distinct genes.
Specifically, isoform-specific alterations of Akt, the serine-threonine kinase whose 3 isoforms are encoded by distinct genes and frequently overexpressed in numerous cancers, were recently found to have divergent effects in ovarian cancer cells and the nearby microenvironment (Linnerth-Petrik et al., 2016).
The molecular chaperones HSP90 comprise two homologous proteins, HSP90α and HSP90β, that are encoded by distinct genes [28].
The various isoforms of each subunit are encoded by distinct genes, with alternative promoters and splice variants, adding to genetic and post-translational complexities [5].
PanK1α and PanK1β are encoded by the same gene and arise from the use of alternate initiation exons [4], whereas the PanK2 and PanK3 isoforms are encoded by distinct genes [5], [6].
These proteins are encoded by distinct loci and exist as alternatively spliced variants [ 1].
AMPK subunits are encoded by distinct genes located at different chromosomal regions (Table 2).
