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While a comI locus has been predicted for B. subtilis spizizenii DSM15029 and B. subtilis natto BEST195, it remains to be elucidated whether these loci encode for a functional competence inhibitor.
However, it remains to be elucidated whether these cell-cycle regulators are involved in cell-fate acquisition directly or through their conventional functions in cell-cycle regulation.
It remains to be elucidated whether these genes code for an efficient T1SS.
It remains to be elucidated whether these strategies are more effective and less toxic.
It remains to be elucidated whether these functions are independent or whether the syndecan-mediated temporal activation of small GTPases could be a consequence of the recycling pathway.
It remains to be elucidated whether these agents have a differentiation effect on the CD133+ population or CSCs in thyroid cancer.
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It remains to be elucidated whether frequent assessment of health status as in the current study negatively, or perhaps positively, influences health outcomes.
Despite these findings, the impact of NURR1 expression has yet to be elucidated in breast cancer.
Other individual factors may be important for different SPMs and only with larger numbers of patients and longer follow-up can these be elucidated.
Nevertheless, many research issues remain to be elucidated, particularly at the smaller scales where new visualization techniques are most applicable.
Whether EPEC infection could be responsible for promoting such mutations remains to be elucidated - analysing this subset of sporadic tumours for EPEC infection could help to answer this question, though clearly an observed EPEC infection may be independent of (and consequent to) the carcinogenic event.
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