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Luminal expansion during organogenesis begins to be elucidated in several systems but we still lack a mechanistic view of the process in many organs.
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In the next section, the focus is on more fundamental, dynamic characteristics of selected intensified process categories, which are elucidated in several examples.
The biosynthetic pathways of hormones have been elucidated in several model organisms [ 59- 61].
Clinical relevance of polarographic determination of tumor oxygenation was elucidated in several clinical studies.
The whole genome DNA-binding profile for CTCF has been elucidated in several cell systems (see, for example, [ 6- 9]).
Their structure has been elucidated in several organisms by manual curation, aided by functional genomic data [ 9, 11, 12].
The role of whole-body bone scan has been elucidated in several cancers including breast cancer, [ 9] non-small cell lung cancer, [ 10] and prostate cancer[ 11].
Although the reactions leading to genistein and 2'-hydroxygenistein biosynthesis have been elucidated in several plant systems, the molecular identities of the isoflavone prenyltransferases are still unknown.
The importance of the SR in Ca2+ signalling and contraction has been elucidated in several smooth muscles, with details of its contribution to agonist stimulation and excitability being understood [25].
The link between Akt2 and breast cancer has been elucidated in several studies [ 15, 22], but the effect of Akt2 on tumour metastasis and growth in vivo has not been demonstrated until recently [ 1].
The three-dimensional structure of RNase H has been elucidated in several organisms, including retroviruses (HIV-1 and MoMLV), bacteria [ Escherichia coli, Thermus thermophilus HB8 and Bacillus halodurans (Bh)] and eukaryotes (humans) [ 14– 14].
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