It remains to be elucidated in future investigations comprising larger populations, focusing on specific disease subtypes and employing more pertinent study-designs, whether this association is genuinely protective.
However, the precise mechanisms of this inhibition may be more complicated and remain to be elucidated in future studies.
However, the consequences of in vivo NP-Pt administration are not well documented and must be elucidated in future research [9].
The use of new plaque classification schemes aimed at identifying unstable or advanced plaques (such as using the napkin-ring sign [41]) remains to be elucidated in future trials.
However, since most of these results are actually derived from in vitro data and definite proof of druggable EMT in vivo is still missing, the clinical utility of these approaches remains to be elucidated in future studies.
Whether the observed reduced levels of HCRT-1 levels in the CSF of CH patients truly reflects a hypofunction of hypothalamic descending antinociceptive signaling, or is simply an epiphenomenon, perhaps reflecting overall hypothalamic hypofunction, remains to be elucidated in future studies.
Nonetheless, there are still some issues that need to be elucidated in future studies.
The identity of the Ssk1-independent signaling component(s) upstream of the Ssk2-Pbs2-Hog1 MAPK module will be elucidated in future studies.
The role of epigenetic alterations in the brain cell populations as a causal factor in the transcriptome and behavior alterations remains to be elucidated in future studies.
Hrk1 is a protein kinase downstream of the Hog1 MAPK and yet has the potential to be modulated by other signaling pathways, which will be elucidated in future studies.
This phenomenon in males could potentially be elucidated in future studies by exposing the male and female animals to additional stressors that could alter the performance in females more than males and change cognitive performance and or/strategies on other special tasks, such as the Morris Water Maze.
