However, cystatin C level may be elevated in patients with diabetes, thyroid disease and in those with elevated levels of inflammatory markers [ 30] as well as in those treated with steroids (15 patients in this study with median daily dose of 7.5 mg prednisolone) [ 31].
Src activity has been observed to be elevated in a murine model of thyroid cancer, and hyper-activation of Src is associated with HIF activity, at least in this model (20).
Cav-1 expression has been shown to be elevated in various malignancies such as colon (Fine et al, 2001), thyroid (Ito et al, 2002), lung (Ho et al, 2002) and bladder (Fong et al, 2003) cancers.
Recently, microchimeric cells were found to be elevated in specific target tissues, such as the liver in hepatitis C infection [ 7] and tumors, such as HER2-positive breast cancer, cervical, lung and thyroid cancer, and melanoma [ 8– 10].
In human tissues, SLC4A11 expression is elevated in kidney, salivary glands, thyroid gland and testis (3).
CLDN7 was elevated in cancers of the thyroid, lung, stomach, pancreas, liver, kidney, and ovary.
There were no effects on growth or development at this stage, but circulating thyroid hormone was elevated in the 20, 60 and 180 μg/L treatments and minimal to mild thyroid follicular cell hypertrophy was observed histologically in the 180 μg/L treatment.
In an earlier study, we reported that nuclear Ep-ICD accumulation predicted poor prognosis in thyroid carcinomas and was elevated in patients with anaplastic tumors [ 33].
Results from previous studies indicated that its expression was elevated in several cancers, such as human thyroid cancer, meningiomas, breast cancer and oesophageal cancer [22, 23, 24, 25].
Vascularization indices were elevated in cases of newly diagnosed benign thyroid diseases.
