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Alpha-1-acidglycoprotein is known to be elevated in systemic tissue injury, inflammation and infection.
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α-tryptase is elevated in systemic mastocytosis.
Procalcitonin (ProCT) is elevated in systemic bacterial infections, but remains low in viral infections.
Compared to normal skin fibroblasts, mPGES-1 protein expression was elevated in systemic sclerosis (SSc) fibroblasts and in bleomycin-exposed mice.
IL-6 is the primary regulator of the hepatic acute-phase response, is elevated in systemic inflammation, and increases with obesity (2).
Circulating levels of ProCT are elevated in systemic bacterial infections but remain relatively low in viral infections and inflammatory diseases [ 26, 27].
Atacicept is a fusion protein that inhibits B-cell stimulating factors BLyS and APRIL, which are elevated in systemic lupus erythematosus (SLE).
Although much less likely than CRP to be elevated in patients with systemic inflammation but without sepsis, elevations of PCT are not as specific for infection as was once believed.
Previously, suPAR has been shown to be elevated in conditions involving severe systemic inflammation [14 16].
Procalcitonin (PCT) has been used as a biomarker in septic patients but has limited specificity and can be elevated in other scenarios of systemic inflammatory response syndrome (SIRS).
TNFα has been reported to be elevated in sera of some patients with systemic lupus erythematosus (SLE), DLE and SCLE, but not in that of patients with DM [ 17- 20].
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