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Using this platform, we identified a protein (SAA) known to be elevated in active SJIA.
Although the serum levels of some cytokines and matrix metalloproteinases (MMPs) have been found to be elevated in active disease, there is a general lack of information about biomarker profiles in AS and how these are related to disease activity.
Serum levels of some cytokines and MMPs have been found to be elevated in active disease, but there is a general lack of information about biomarker profiles in AS and how these are related to disease activity and function.
C-reactive protein (CRP) is known to be elevated in active disease and to decrease upon effective treatment in SpA, but is less useful than in rheumatoid arthritis (RA) as two thirds of the SpA patients have normal CRP levels [ 11- 14].
Objective measures of inflammatory activity, such as C-reactive protein (CRP) or erythrocyte sedimentation rate, may not be elevated in active AS. 1 Recent randomised, placebo-controlled studies have shown that MRI can objectively assess the effect of AS treatment interventions.
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FFAs are elevated in active muscles and might activate the PPARs during activity (Nawrocki & Gorski, 2004).
The maximum SUV is elevated in active TB.
In addition, plasma levels of various proangiogenic molecules are elevated in active MM.
We have already demonstrated that circulating PDGF-BB was elevated in active CD and UC [ 27].
IP-10 secretion was elevated in active TB patients after stimulation with M. tuberculosis antigens [ 31- 36, 40, 43, 44].
Comparing active and inactive TAO, serum Th1 cytokines IFN- γ and TNF- α were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com