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A trivial explanation for doxycycline-independent tumor viability could be either the aberrant expression of MYC independent of doxycycline or endogenous upregulation of murine c-Myc.
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The program identified aberrant sites that were either the result of a double mutation, recent gene flow between species or ancient polymorphisms.
Perhaps the strongest experimental evidence for the existence of aberrant cells created by low morphostat levels are foreign-body implant experiments investigating preneoplastic cells (that could be either aberrant cells or cells derived from aberrant cells).
For the reasons outlined above, we focused our differential gene expression analysis on a 5 Mb 2p interval (including the 1 Mb 2p region analysed by ChIP) likely to be either physically or spatially positioned close to aberrant heterochromatin foci (Fig 4A).
We can only speculate that these are either aberrant accumulations of Rrm4-containing mRNPs or that these are Rrm4-containing mRNPs in the process of assembly that cannot be loaded on endosomes, because Upa1 is not supporting their loading.
A second point that needs to be emphasized is the aberrant nature of Trump's attacks on the press.
Swallowing accelerometry has been used to detect aspiration in several studies, which have described a shared pattern among healthy swallow signals, and verified that this pattern is either absent, delayed or aberrant in dysphagic swallow signals [22 34].
This shows that the majority of cancers with high nuclear β-catenin staining (n=56) are either SMAD4 negative and/or p53 aberrant (n=46/56, 82%).
Monoclonal plasma cells are either CD19/CD56 or CD19/CD56 and thus phenotypically aberrant.
Accordingly to this view, several genes controlling cell division/differentiation have been involved to prevent either the aberrant growth of the cortical primordium or the depletion of long term proliferating cells [67], [68], [69].
It may thus be necessary to look for either the aberrant activation of target genes of the Notch signalling pathway or for nuclear localisation of the NICD fragment.
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