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H4R expression on Th17 has been described, and histamine stimulation of these cells increased IL-17 secretion and overall activation [68], suggesting that these cells might also be efficiently targeted by H4R antagonists.
Using an efficient computational model, we provide an extensive library of possible linker molecules between individual zinc finger motifs in the construct that can skip up to 10 base pairs between adjacent zinc finger recognition sites in the DNA sequence, which increases the number of genes that can be efficiently targeted by more than an order of magnitude.
This will be a valuable step that might help determine if, and to what extent the host protein can be efficiently targeted by novel antiretroviral drugs.
On the other hand it is well possible that TA targets a yeast cellular pathway that is either absent in mammals or that is too divergent to be efficiently targeted by this drug.
A small percentage of farms (<20%) contribute the bulk of the transmission potential (>80%) and these farms could be efficiently targeted by interventions aimed at reducing spread of diseases via animal movement.
These results showed that the C57BL/6NJ inbred strain could be efficiently targeted by CRISPR/Cas9 delivered by electroporation.
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Clefts are efficiently targeted by the HT signal.
Moreover, the population of highly tumorigenic CSCs was efficiently targeted by MT110 in vitro and in vivo.
Thus, Mcl-1, which is efficiently targeted by wogonin, may be the most relevant therapeutic target in multiple types of cancer.
In fact, if only 60% of populations at risk are efficiently targeted by control programs, effects on disease transmission will be very limited.
Chicken BAF60a and BAF60b 3′UTR sensor constructs containing target sites for either miR-133 or miR-1/206 miR-1/206ciently targeted by miR-133 or miR-1/206 (Fig. 3C; supplementary material Fig. S3C).
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