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The nanocapsules were demonstrated to be efficiently internalized into the cells and to release the protein in the reducing cytosol.
The FITC-CS@MNPs described here could be efficiently internalized into SMMC-7721 because of their electrostatic interactions with the cell membrane.
The in vitro results demonstrated that the as-synthesized nanoprobes could be efficiently internalized into A549 cells and then significantly enhance the mortality of cancer cells compared with free Ce6 and doxorubicin.
As can be seen in Figure 6, HeLa cells showed strong green (Figure 6B) and red (Figure 6C) fluorescence, indicating that pIRES2-EGFP-loaded and pDsRED-loaded TPGS-b- PCL-ran-PGA)/PEI nanoparTPGS-b- PCL-ran-PGAicienTPGS-b- PCL-ran-PGATPGS-b- PCL-ran-PGA
We expected that the nanoparticles could be efficiently internalized into cells with lowest toxicity.
To function as a targeted drug carrying platform, the antibody complexed phages should be efficiently internalized into the target cells.
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A2 was efficiently internalized into both cell lines via at least two different mechanisms.
Fluorescence-labeled siRNA formulated in CPP-LNP was efficiently internalized into B16F10 murine melanoma cells in a time-dependent manner, although that in LNP without CPP was hardly internalized into these cells.
Confocal microscopic images showed that siRNA formulated in αHB-EGF LNP-siRNA was efficiently internalized into MDA-MB-231 human breast cancer cells, on which HB-EGF is highly expressed.
They could form a nuclease-resistant stable nano-complex with siRNA, which was efficiently internalized into cells achieving targeted gene silencing in the presence of serum with a remarkably low cytotoxicity.
The focus is also on mAbs that are efficiently internalized into cells once they bind to the target antigen, engineered mAbs that are designed for efficient drug delivery, new drugs with high potencies, and linker technology to accommodate these novel agents.
More suggestions(17)
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be efficiently programmed into
be efficiently transported into
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