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Moreover, the particles could be efficiently internalized by FA-receptor-rich MCF-7 cells through the receptor-mediated endocytosis, whereas FA-receptor-poor HEK-293T normal cells showed much lower endocytosis of the nanoparticles under the same conditions.
The laden micelles exhibited stable morphologies in normal physiological condition and could be efficiently internalized by RenCa cells (a mouse renal carcinoma cell line).
The silica-coated CdSe QDs were found to be efficiently internalized by cancer cells and stem cells in vitro, thereby highlighting their potential to be used as a non-toxic optical probe for biomedical diagnostics as well as cellular labelling applications.
The previous experiments showed that a PM-associated protein can be efficiently internalized by a C-terminal fusion to ubiquitin.
For the recombinant toxin conjugates to be active, they must be efficiently internalized by the cell surface protein to which they are targeted by the fusion partner.
Cyclic heptapeptide cyclo(FΦRRRRQ) (cFΦR4, where Φ is l-2-naphthylalanine) was recently found to be efficiently internalized by mammalian cells.
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In agreement with previously reported results [13], the plasmid-cured avirulent Y. pseudotuberculosis strain YPIII was efficiently internalized by control HeLa cells (69% internalization) (Figure 3B), whereas the corresponding wild-type strain remained largely extracellular (11% internalization) (Figure 3B).
In vitro studies showed that protamine nanocapsules were efficiently internalized by macrophages without eliciting significant toxicity.
Cell culture analysis by microscopy and flow cytometry revealed that the prodrug nanogels were efficiently internalized by tumor cells.
We found that the CuDox complex was efficiently internalized by mammary carcinoma cells after release from LTSLs.
All EpCAM-specific DARPins were efficiently internalized by receptor-mediated endocytosis, which is essential for intracellular delivery of anticancer agents to tumor cells.
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