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Furthermore, SCARB2-mediated uncoating can be efficiently blocked by the "pocket factor" analog NLD.
These results indicate that the HCV life cycle can be efficiently blocked by using properly-designed siRNAs that target functionally important, highly conserved sequences of the HCV IRES.
In conclusion, SAH induces a pro-inflammatory environment in the lung, which can be efficiently blocked by IFN-β.
SAH-animals had a significant increase in MPO-activity compared to sham-animals (P < 0.01), which could be efficiently blocked by IFN-β (P < 0.01; Figure 1a).
Notably, although degradation steps could be efficiently blocked by addition of Baf, our assay does not rely on addition of lysosomal inhibitors to infer autophagic flux.
As showed in Figure 2D, the binding of the fusion protein to A431 cells can be efficiently blocked by the addition of EGF, which binds exclusively to EGFR.
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Moreover PC4-mediated proteolysis was efficiently blocked by a newly designed prodomain rPC4101 116 peptide with IC50 in low μM level.
Moreover, the local acute inflammatory response in this animal model was efficiently blocked by expression of the anti-inflammatory cytokine interleukin-10 (IL10) driven by our LV system.
With this NWA electrode, the electrochemical responses were significantly enhanced for the binding event of streptavidin to the biotinylated FLVs (~ 220 times increase in signal amplification as compared to bare electrode) and the electron transfer was efficiently blocked by the captured liposome.
The generation of ROS by a cascade of reactions is efficiently blocked by various endogenous antioxidants to overcome their potentially injurious actions [2], [3].
Moreover, we observed that TNF-α-induced upregulation of antiapoptotic protein XIAP and FLIP was efficiently blocked by inhibiting LRP16 expression in 293T cells (Figure 7C).
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