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In this context azelnidipine [ 25] and ranolazine [ 26] have also been shown to be efficient at reducing intracellular calcium accumulation.
Thus, promoting RTK ubiquitination and degradation by targeting c-Cbl may prove to be efficient at reducing tumor growth and metastasis in cancers in which RTK expression is excessive.
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Since 3-MA treatment may induce off-target effects, we further confirmed that 3-MA treatment was efficient at reducing the number of LC3-positive autophagosomes in TzbR cells.
In support of this concept, proteasome inhibitors were efficient at reducing tumorigenesis, specifically in myeloid disorders.
PSV is efficient at reducing mechanical ventilation-induced proteolysis and inhibition of protein synthesis without modifications in the level of oxidative injury compared with continuous mechanical ventilation.
Infiltration systems were found to be efficient at attenuating high-flow hydrology (reducing peak magnitudes and frequencies) at a range of scales (parcel, streetscape, catchment).
Be efficient at the security check-point.
A new stack-die packaging structure with an embedded capacitor has been introduced and proven to be efficient in reducing parasitic ringing at the turn-off transition and achieving true zero-voltage-switching turn-on.
kyp mutations were shown to specifically reduce H3K9m2 in vivo, and KYP is efficient at mono- and di- methylation, but not trimethylation, of H3K9 sites in vitro [34].
Interestingly, as stated previously, post-translational degradation of p53 by Mdm2 increases both p yz and p z (degradation rate), while a hypothetical transcriptional suppression would only increase p yz. Hence post-translational suppression of p53 may be more efficient at reducing steady-state error than transcriptional suppression, even though it is less energy efficient.
In Australia, modelling has shown that volumetric taxation, that is, applying the same rate of tax per litre of alcohol across all beverages, would be most efficient at reducing alcohol harm [ 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com