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Nevertheless, none of these strategies demonstrated to be efficacious when translated to humans12, and there is still the need for alternative approaches and new targets to be identified.
Prescription nail lacquers like ciclopirox have been clinically tested and approved by the Food and Drug Administration, and shown to be efficacious when used as directed, though not as effective as oral drugs; over-the-counter topicals are also available but have not been tested.
Paclitaxel is an established chemotherapeutic drug and has been shown to be efficacious when conjugated to various anti-cancer agents [51].
Aspirin was found to be efficacious when administered in this way, but curcumin was inactive.
11, 12 In addition, multiple trials have demonstrated varenicline to be efficacious when compared to other active treatments.
Medications shown to be efficacious when used to augment antidepressant treatment include lithium, thyroid hormone, buspirone, and bupropion.
Similar(49)
Although comprehensive school-based physical activity interventions are efficacious when tested under research conditions, they often require adaptation in order for implementation at scale.
The aim of this literature search is to establish if metformin is efficacious when given to clomiphene citrate (CC resistant polycystic ovary syndrome (PCOS) patients.
Although the vaccine is efficacious when tested in an experimental setting, policymakers are more likely to use this vaccine after receiving evidence demonstrating protection when delivered to communities using local health department staff, cold chain equipment, and logistics.
Compound 39 was highly potent versus PDE10A (IC50 = 1.0 nM), demonstrated high selectivity (>1000-fold >1000-foldther PDEs against efficaciotherhen dosed orally in a rat model of PDEshosis, PCP-induced hyperlocomotion with andEC50 of 1 mg/kg.
The studies described in this article show that the nicotinic antagonist mecamylamine is efficacious when administered in combination with nicotine replacement.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com