6 7 8 9 10 These trials have also highlighted that, although methotrexate monotherapy can be efficacious, it does not provide optimal disease control in a proportion of patients.
If interim imaging can predict early in the course of therapy that a specific treatment will not be efficacious, therapy can potentially be altered prior to completion of the entire course.
If CCOS can be demonstrated to be efficacious will it prove to be cost-effective?
These case reports show that gefitinib monotherapy can be efficacious in chemonaive patients, and can cause sustained responses at primary and metastatic sites, a finding that was supported by other EAP investigators' reports.
56, 57, 59 Efficacy and tolerability associated with ChEIs are dose dependent, 60 so while high doses may be efficacious, adverse events (AEs) can be dose limiting.
If the Pain Barometer is proven to be feasible and Move It Now appears to be efficacious, a health care pathway can be created to provide the best tailored treatment promptly to adolescents with chronic pain.
Thus, although protective immune responses against FMD virus (FMDV) can be efficacious, the rapidity of virus replication and spread can outpace immune defence development and overrun the immune system.
Although protective immune responses from vaccination against FMDV can be efficacious, the rapidity of virus replication and spread can outpace the development of immune defenses and overrun the immune system (Summerfield et al., 2009).
In addition, although lithium augmentation can be efficacious within 48 hours of its administration [ 4] delayed responses (up to 8 weeks) have also been frequently observed [ 3].
However, among the few patients who had a timely diagnosis, systemic chemotherapy is efficacious and can prevent further neurological deterioration.
