In particular, he noted that foxglove leaf preparations were efficacious in small, nontoxic doses and that their action varied according to the plant's stage of bloom.
Again, the majority of evidence in ophthalmic literature suggests ECP is efficacious in small case series or in small trials but emphasis is for highly specific complicated or refractory indications.
Thus, chronic dosing via food pellets is efficacious in small rodents, even with a low drug dose design, and can prevail against potential confounds in translational research within depression models applicable to adverse chronic invasive pharmacotherapies.
The concept of interrupting the myocardial reperfusion process with the angioplasty balloon to reduce myocardial IS (as assessed by different modalities, including cardiac biomarkers) has been demonstrated to be efficacious in several small-size studies evaluating STEMI patients undergoing PPCI [ 10, 19, 21, 26].
Our results support the suggestion that RIT could be efficacious in CRC patients with small liver tumors that cannot be diagnosed at the time of surgery of the primary tumor and constitute an enhanced risk of disease recurrence.
Core decompression, one of the least invasive surgical procedures, may be efficacious in early stages and small-size lesions of osteonecrosis, although concerns have been raised because of its potential to weaken the cancellous bone within and adjacent to the necrotic area (Scully et al. 1998, Lavernia and Sierra 2000).
As discussed, RTX has been shown to be efficacious in a growing number of small case series in steroid-sensitive and steroid-dependent MCD; however, reported success of its use in multi-drug-resistant disease, particularly in adults, remains limited.
Print-delivered as well as on-line computer-tailored health advice has been shown to be efficacious in changing behaviours, even though effect sizes mostly are small [ 8- 12].
One of the grand challenges in kinase drug discovery is the design of small-molecule inhibitors with selectivity profiles that will ultimately be efficacious in the clinic.
Developer-led trials of both have shown them to be efficacious in reducing symptoms of depression.
