Sentence examples for be efficacious in mouse from inspiring English sources

Notably, this is the same dose of DFMO that has been shown to be efficacious in mouse models of colon tumorigenesis [35].

These vaccines elicited high-titer antibodies that were efficacious in mice and ferret models [14], [15].

In fact, recently published studies demonstrate that FGF21 is efficacious in mice even in the absence of Ucp1 gene (Samms et al., 2015, Véniant et al., 2015).

In conclusion, our results indicate that ICV infusion leads to widespread hASM delivery throughout the CNS in rats at a level shown to be efficacious in ASMKO mice.

Nevertheless, despite the fact that only a small percentage of the total ICV administered dose was detected in rat CNS parenchyma, hASM was distributed throughout the CNS and at a level (2 10 ng/region) that is predicted to be within the therapeutic range necessary to be efficacious in the ASMKO mouse CNS [16].

To assess the anticancer effects, the NVP-BEZ235 dose was reduced to 45 mg kg−1, q.d., which is a dose and schedule that have been shown to be efficacious in in vivo mouse xenograft human cancer models (Maira et al, 2008).

A number of immunostimulants, such as anti-CTLA4 antibody [1], have been shown to be efficacious in treating established tumors in mice and several of these agents have advanced to clinical trials in humans.

Compound 46 was further tested for in vivo efficacy and found to be efficacious in ovalbumin-induced allergic asthma model in mice.

Finally, both oestradiol and oestriol have been shown to be efficacious in both female and male mice with EAE [ 131].

The present study is designed to explore whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of AD through SIRT1 signaling.

The human-mouse chimeric monoclonal antibody (mAb) cocktail ZMapp, previously shown to be efficacious in EBOV (variant Kikwit) lethally infected nonhuman primates (NHPs) when administration was initiated up to 5 days, was used in some patients during the outbreak.