Honigberg, L. A. et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy.
RECENT ADVANCES: Metalloporphyrins are efficacious in models of amyotrophic lateral sclerosis, Alzheimer's disease, epilepsy, neuropathic pain, opioid tolerance, Parkinson's disease, spinal cord injury, and stroke and have proved to be useful tools in defining roles of superoxide, nitric oxide, and peroxynitrite in disease progression.
The primary goal of the studies reported here was to determine whether Irinophore C™ is efficacious in models of GBM, and whether treatment with this drug formulation would also result in normalization of GBM vasculature.
AAV for pain targeting the peripheral nervous system was proven to be efficacious in rodent models several years ago, but has not yet been tested in humans.
The title compound was found to have the best overall potency and pharmacokinetic profile and was found to be efficacious in animal models of diabetes and cancer.
We chose a dose greater than previously demonstrated to be efficacious in murine models of fibrosis [22].
Notably, this is the same dose of DFMO that has been shown to be efficacious in mouse models of colon tumorigenesis [35].
These compounds produced mixed cannabinoid receptor/T-type channel blockers that were found to be efficacious in animal models of inflammatory and neuropathic pain.
That chondroitinase gene therapy has now been shown to be efficacious in contusion models at either thoracic or cervical level is an important step in the further development of this promising therapeutic strategy towards the clinic.
Previous study shows a neutralizing VLA-4 antibody, in conjunction with cytarabine, prevented the development of AML in a xenograftmodel, supporting the role of VLA-4 in the sensitivity of AML cells to chemotherapy, whereas targeting CXCR4 with small-molecule pharmacologic inhibitors has been shown to be efficacious in preclinical models of AML.
