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Although atomoxetine is reported to be efficacious in both adolescents and young adults, no longitudinal studies have been designed to assess directly the effects of atomoxetine treatment during this transition period.
These properties suggest that this compound could be efficacious in both hormone-independent prostate and breast cancer.
Finally, both oestradiol and oestriol have been shown to be efficacious in both female and male mice with EAE [ 131].
90, 91 Ceritinib was found to be efficacious in both ALK+ patients who have previously received crizotinib and crizotinib naive patients.
However, it would appear that a core set of pathways (TP53, RB1/cell cycle, and PI3K/AKT/mTOR) is compromised in both HPV+ and HPV- oropharyngeal tumors, thus targeted therapies directed against one or more of these pathways could be efficacious in both contexts.
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This would explain why STA-5326, blockinging both IL-12 and IL-23, is efficacious in both phases.
Artemisinin derivatives result in rapid parasite clearance and are efficacious in both uncomplicated and severe knowlesi malaria.
Pemetrexed was only efficacious in a non-squamous population and erlotinib was efficacious in both the intent-to-treat and stable disease populations.
These two models are driven by different pro-angiogenic growth factors; bFGF drives the in vivo model and VEGF drives the in vitro model; despite this STX2484 was efficacious in both models.
Moreover, it has been reported that the combination of epigallocatechin gallate (EGCG) and curcumin is efficacious in both in vitro and in vivo models of ER α-breast cancer by the regulation of VEGFR-1 expression [ 24].
As well as confirming that CDP7657 was efficacious in both rodent and Cynomolgus monkey models, it was important to determine whether this construct mitigated the Fc-mediated platelet activation believed to be responsible for the prothrombotic events observed with hu5c8.
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