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I could list literally a dozen more examples, but you get the idea: because we balkanize biomedical research, biomedical-research funding, and pharmaceutical industry drug development according to phenotypically classified diseases, the possibility that a drug that has failed the efficacy test in one disease might be efficacious in a completely different one has not permeated the culture.
Similarly, psychotropic treatments ranging from lithium and antipsychotics to serotonin reuptake inhibitors (SSRIs) and acetylcholinesterase inhibitors have been shown to be efficacious in a wide spectrum of psychiatric disorders ranging from autism, schizophrenia (SZ), depression, and bipolar disorder (BD) to Alzheimer's disease (AD).
CBZ and OXC were confirmed to be efficacious in a large majority of patients, but the side effects caused withdrawal from treatment in an important percentage of patients.
We are also interested in research to test the feasibility and effectiveness of larger-scale implementation of a strategy previously shown to be efficacious in a smaller-scale experiment.
CBZ and OXC were confirmed to be efficacious in a large majority of patients, but the side effects caused the withdrawal from treatment in an important percentage of patients.
The maximally tolerated dose of 80-120 mg/m2 in pretreated patients (which is similar to those reported with cisplatin alone) and median intraperitoneal temperatures of 40.7 degrees C, however, are felt to be too low to be efficacious in a significant percentage of women with bulky recurrent disease.
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EPA and DHA supplementation was found to be efficacious in an open label study of schizophrenia patients treated with haloperidol [ 63].
Therefore, although there is limited specific evidence, this treatment is likely to be efficacious in an environment when nearly all patients receive temozolomide as part of initial management.
Second, a drug may be efficacious in an animal model but not in humans, thus exposing humans to the risks associated with the drug despite having no possible good come from taking the drug.
The high bioavailability of famciclovir (77%) and the rapid onset of viral replication in recurrent genital herpes suggested that this medication would be efficacious in an even shorter single-day treatment regimen.
Compound 22 was efficacious in a murine allergic inflammation model (ED50 ∼ 10 mg/kg).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com