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Agonist compounds, on the other hand, would likely be efficacious due to the widespread presence of NPY receptors but could therefore have severe pleiotropic effects.
The standard treatment for non-MDR TB involves combination therapy of more than three drugs; R and isoniazid (H) provide a crucial backbone to ATT regimes, allowing shorter courses of 6 to 9 months (1 year for CNS TB) to be efficacious due to their bacteriocidal action.
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In summary, this is a well conducted trial showing that treatment efficacy is possible in the frail elderly group in whom oral bisphosphonates is less efficacious due to side effects and noncompliance.
The DPP-4 inhibitors sitagliptin and vildagliptin have already been approved in many countries and have been shown to be efficacious and safe due to their DPP-4 selectivity.
Any effect of the plants claimed to be efficacious against scorpion stings may be due to symptomatic relief – analgesic, antiinflammatory, antipruritic effects, in addition to other biological activities [ 11].
Standard chemotherapy remains the backbone of systemic triple negative breast cancer (TNBC) treatment even amidst advances in cancer treatment as neither hormonal therapy nor anti-HER2 agents are efficacious against TNBC due to the absence of a target [73].
This suggests that a recombinant vaccine designed to be efficacious in Africa and Asia is likely to be efficacious in South America.
Although hormone replacement therapy has been proven to be efficacious in preventing bone loss, yet, it is not desirable to many women due to its side effects [ 3].
The loss of statin efficacy is likely due to increased circulating PCSK9 and antibody therapy against PCSK9 has been found to be efficacious in lowering LDL-C.
Developer-led trials of both have shown them to be efficacious in reducing symptoms of depression.
Cidofovir has been found to be efficacious in treating RRP.
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