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In this study, we aimed to use the lowest dose of the cannabinoid agonist, ACEA (1 mg/kg) that might be efficacious, based on previous studies.
Doses of buparlisib ≥50 mg/day led to steady-state exposure levels ≥10 000 ng*h/mL, which are estimated to be efficacious based on preclinical studies.
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Through 2 years of blinded treatment in this first head-to-head study between biologic disease-modifying antirheumatic drugs in RA patients with an inadequate response to MTX, subcutaneous abatacept and adalimumab were similarly efficacious based on clinical, functional and radiographic outcomes.
Regulatory requirements are designed to assure that products are safe for their intended use, free from contamination and infection and efficacious based on scientific evidence and product characteristics.
Knowledge is based on forgetting.
These treatments seem to be extremely efficacious and are based on the notion that the microbial populations within the stool of the healthy donor are able to repopulate and colonise the abnormal gut of the patient and thereby affect a cure.
Aluminum salts (Alum) have proven to be efficacious for recombinant-protein based formulations in which Th2 responses are very effective.
To date, the only drug shown to be efficacious on both the incidence of vasospasm and poor outcome is nimodipine.
In order to be efficacious and effective, behavioural interventions should be based on an understanding of mechanisms and processes as described by empirically-tested theoretical frameworks.
The checklist was not subject to rigorous scientific analysis because we thought that the surgical safety checklist it is based on has already proven to be efficacious.
Although this dosing strategy appears efficacious, it is based on clinical trials rather than pharmacokinetic (PK pharmacodynamic (PD) assessments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com