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These findings can serve as a positive indication that a drug may be efficacious, and further study should be initiated.
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Considering the relationship between in vitro potency and concentration achieved in mice, compounds with a Cmax/TRE of ≥30, AUC0 48/TRE of ≥587, and T>TRE of 100% would likely be efficacious and would be prioritized for further studies.
Further work is needed to determine whether such interventions will be efficacious and whether they may be feasible to implement in SSA.
Long-term infliximab therapy seems to be efficacious and safe.
However, among the few patients who had a timely diagnosis, systemic chemotherapy is efficacious and can prevent further neurological deterioration.
Coiling is efficacious and safe, but durability needs improvement, as nearly 20% of patients require further invasive intervention secondary to aneurysm recurrence.
This would further confirm that local infiltration of analgesics periarticularly is efficacious and can therefore be recommended for analgesia following TKA.
Further follow-up needs to be undertaken to determine whether vaccination is efficacious and cost effective in adults age 50 59.
The two combinations tested were efficacious and appeared safe.
Most users perceived that herbs were efficacious, and in some instances, more efficacious than conventional medicines.
The procedure is efficacious and comparable to pre-operative localisation.
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