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Recent studies have shown that mutant EZH2-driven tumors can be effectively targeted with small molecule inhibitors.
Data emerging from recent neoadjuvant clinical trials suggest that HER2+ disease can be effectively targeted with additional agents aimed at HER2 such as lapatinib [26] and pertuzumab [27].
Despite many efforts the number of genes that can be effectively targeted with ZFNs remains severely limited, as available constructs cannot address arbitrary gene sequences.
The genomic instability of BRCA1-mutated tumors can be effectively targeted with DNA-damaging agents and poly- ADP-ribose) poly- ADP-riboseRpoly- ADP-ribose
These studies could, for example, aid in the development of a risk index that reliably identifies children who could be effectively targeted with early intervention approaches [ 116].
Several groups have shown that HER2+ breast cancer models that have been selected for trastuzumab resistance can be effectively targeted with PI3K or AKT inhibitors [ 9, 10].
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FSS can be effectively targetted with CBT and mindfulness-based interventions in adults [ 73, 74] and in children [ 75].
These have been effectively targeted with dramatic reductions in infant and child mortality and there has been a steady improvement in life expectancy over the past thirty years [ 12].
For example, abnormal PI3K activation in breast cancer can occur though amplification of the HER2 gene, the gene product of which is effectively targeted with the monoclonal antibody trastuzumab [ 3].
Data presented here confirm that breast cancer cells can be effectively targeted by nanoparticles with a folate receptor-dependent mechanism of cell uptake.
Results suggested that mannosylated vesicles could be effectively targeted to the model bacterial bio-films, compared with plain vesicles.
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